It's a safe guess that Danny DeVito and Rhea Perlman didn't have to audition for their guest roles on ABC's new drama "Karen Sisco."

DeVito is an executive producer of the series, based on Elmore Leonard's "Out of Sight," and Perlman has been married to him for more than 20 years. As they say, it's who you know.

The couple will appear together in an episode of the show this fall. DeVito will play Charlie Lucre, a South Florida mob boss who becomes a crime victim himself when his prized Babe Ruth-autographed baseball is stolen by two dim-bulb brothers who recently escaped from prison.

Federal marshal Karen Sisco (Carla Gugino) is assigned to track the brothers down before Lucre's goons do. She turns to their mother (Perlman) for help in finding the boys.

DeVito and Perlman have appeared on screen together numerous times, going back to "Taxi" in the late 1970s. They most recently acted opposite each other in the 1996 movie "Matilda."

An airdate for their episode hasn't been set. "Karen Sisco" premieres Wednesday, Oct. 1 on ABC.